Tadalafil (similar to Cialis), 2000mg (20mg/100tabs)

$99.29 If paid in BTC $74.47

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Tadalafil (similar to Cialis), 2000mg 20mg

Total amount of active ingredient: 2000mg

Shipping: 
•USA: $6.95 (3-7 business days)
•CA: $10.50 (3-7 business days)
•International: $39 (7-14 business days)
If your shipment was seized (International Orders), we will provide a 50% discount applicable on your next purchase. Please contact us for more information.
Quantity: 100 tabs
Packaging: Bottled

Product made and housed in the USA and Europe.

What is Tadalafil?
This is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis.
It is used for the treatment of pulmonary arterial hypertension and for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when the conditions coincide.
Like sildenafil and vardenafil, tadalafil is recommended as an ‘as needed’ medication. Cialis is also offered as a once-daily medication.

Pharmacodynamics
Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil’s pharmacologic distinction is its longer half-life (17.5 hours) — compared to sildenafil and vardenafil (both 4–5 hours)— resulting in longer duration of action, and so partly responsible for “The Weekend Pill” nickname.
Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells. cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.

The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil’s inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended tadalafil starting dose for most men is 10 mg, taken as needed before sexual activity (but not more than once daily). The dose may be increased to 20 mg or decreased to 5 mg, per its efficacy and the man’s personal tolerance of the drug.
In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as single-daily ED therapy.

Selectivity compared with other PDE5 inhibitors
Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme. These drugs also inhibit other PDE enzymes.
Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil.
Some sildenafil users see a bluish tinge and have a heightened sensitivity to light because of PDE6 inhibition.
Sildenafil and vardenafil also inhibit PDE1 more than tadalafil. PDE1 is found in the brain, heart, and vascular smooth muscle.
It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and tachycardia.
Tadalafil inhibits PDE11 more than sildenafil or vardenafil.
PDE11 is expressed in skeletal muscle, the prostate, the liver, the kidney, the pituitary gland, and the testes.

Cialis (Tadalafil)

Tadalafil is an annulated 2,5-diketopiperazine. It is also a 1,2,3,4-tetrahydro-β-carboline.
Tadalafil can be synthesized starting from (D)-tryptophan methyl ester and piperonal via a Pictet–Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring:

Tadalafil synthesis

All of our products are lab tested and the results are periodically published on the website.

Also known as: 351, IC, Cialis, IC 351, IC-351, IC351, tadalafil

 

Additional information

Weight 0.6 kg

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Tadalafil (similar to Cialis), 2000mg (20mg/100tabs)

$99.29 If paid in BTC $74.47

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