Tadalafil (similar to Cialis) (20mg/100tabs)

83.00$ If paid in BTC 58.10$

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Tadalafil (similar to Cialis) (20mg/100tabs)

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USA & CA: $5 (3-5 business days) 
International: $39 (7-14 business days)
Quantity: 100 tabs
Packaging: Capsulated and in Mylar Bags

What is Tadalafil?
This is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis.
It is used for the treatment of pulmonary arterial hypertension and for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when the conditions coincide.
Like sildenafil and vardenafil, tadalafil is recommended as an ‘as needed’ medication. Cialis is also offered as a once-daily medication.

Pharmacodynamics
Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil’s pharmacologic distinction is its longer half-life (17.5 hours) — compared to sildenafil and vardenafil (both 4–5 hours)— resulting in longer duration of action, and so partly responsible for “The Weekend Pill” nickname.
Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells. cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.

The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil’s inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended tadalafil starting dose for most men is 10 mg, taken as needed before sexual activity (but not more than once daily). The dose may be increased to 20 mg or decreased to 5 mg, per its efficacy and the man’s personal tolerance of the drug.
In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as single-daily ED therapy.

Selectivity compared with other PDE5 inhibitors
Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme. These drugs also inhibit other PDE enzymes.
Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil.
Some sildenafil users see a bluish tinge and have a heightened sensitivity to light because of PDE6 inhibition.
Sildenafil and vardenafil also inhibit PDE1 more than tadalafil. PDE1 is found in the brain, heart, and vascular smooth muscle.
It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and tachycardia.
Tadalafil inhibits PDE11 more than sildenafil or vardenafil.
PDE11 is expressed in skeletal muscle, the prostate, the liver, the kidney, the pituitary gland, and the testes.

Cialis (Tadalafil)

Tadalafil is an annulated 2,5-diketopiperazine. It is also a 1,2,3,4-tetrahydro-β-carboline.
Tadalafil can be synthesized starting from (D)-tryptophan methyl ester and piperonal via a Pictet–Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring:

Tadalafil synthesis

Do not take CIALIS if you:

  • take medicines called “nitrates” such as nitroglycerin or other medications like isosorbide dinitrate or isosorbide mononitrate, which are often prescribed for chest pain as the combination may cause an unsafe drop in blood pressure; or use recreational drugs called “poppers” like amyl nitrite and butyl nitrite.
  • take medicines called guanylate cyclase stimulators such as riociguat (Adempas®)*, a medicine used to treat pulmonary hypertension as the combination may cause an unsafe drop in blood pressure.
  • are allergic to CIALIS or ADCIRCA® (tadalafil), or any of its ingredients. Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, hives, swelling of the lips, tongue or throat, or difficulty breathing or swallowing.

After taking a single tablet, some of the active ingredients of CIALIS remains in your body for more than 2 days. The active ingredients can remain longer if you have problems with your kidney, liver, or if you are taking other medications.

Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if it is already weak from a heart attack or heart disease.

CIALIS is not right for everyone. Only your healthcare provider and you can decide if CIALIS is right for you.

Ask your healthcare provider if your heart is healthy enough for you to have sexual activity. Do not take CIALIS if your healthcare provider has told you not to have sexual activity because of your health problems. Before taking CIALIS, tell your healthcare provider about all your medical problems, particularly if you have or ever had:

heart problems such as chest pain (angina), heart failure, irregular heartbeats, or heart attack
pulmonary hypertension
low blood pressure or high blood pressure that is not controlled
stroke
liver or kidney problems or require dialysis
retinitis pigmentosa, a rare genetic (runs in families) eye disease
severe vision loss, including a condition called NAION
stomach ulcers or a bleeding problem
a deformed penis shape or Peyronie’s disease
an erection that lasted more than 4 hours
blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia

CIALIS does not:
Cure ED, increase a man’s sexual desire, protect a man or his partner from sexually transmitted diseases, including HIV or serve as a male form of birth control.

All of our products are lab tested and the results are periodically published on the website.

We are negotiating and buying in bulk from top peptide and research chemical manufacturers from around the world to bring the end researcher wholesale discounted prices of the highest quality research chemicals. 

Also known as: 351, IC, Cialis, IC 351, IC-351, IC351, tadalafil

 

Tadalafil (similar to Cialis) (20mg/100tabs)

83.00$ If paid in BTC 58.10$

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