Hexarelin (Examorelin) 2mg (price is per vial)

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Hexarelin (Examorelin) 2mg has to reconstituted with Bacteriostatic water (BAC).

You can purchase BAC water here:
BAC 10ml 
BAC 20ml 

Click here to buy 10vials (1KIT) at a discounted price of $130!

Total amount of active ingredient: 2mg (1vial)

Availability: In stock

Top Color: Purple

Shelf Life: 36 months

Shipping:
USA: $11.95 (3-5 business days)
International : $49.95 (7-14 business days)
If your shipment was seized (International Orders), we will give a half rebate relevant on your next buy. Please contact us for more information.
Minimum Order: 1vial

Hexarelin (Examorelin)

Hexarelin is a synthetic growth hormone secretagogue. It is derived from GHRP-6 and has effects similar to ghrelin. The primary function of hexarelin, as shown in animal research models, is to increase plasma levels of growth hormone and promote the development of lean body mass.

Indirectly, hexarelin has been shown to improve cardiac function, lower lipid levels, and protect against the effects of certain chemotherapeutic agents. The peptide is currently under investigation for its ability to mitigate the effects of certain metabolic diseases, such as diabetes.

Hexarelin Peptide
Molecular Formula: C47H58N12O6

Molecular Mass: 887.04022

Amino Acid Sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys

Hexarelin Research Applications
There are a few dynamic zones of hexarelin examine, with the most noticeable including metabolic conditions like diabetes. Hexarelin has recently been shown to activate CD36-PPARγ[1]. PPARs (Peroxisome proliferator-activated receptors) is the objective of numerous pharmaceuticals (for example thiazolidinediones) that improve insulin resistance. Improving insulin resistance helps lower blood sugar levels in type 2 diabetes and regulates lipid metabolism.

Firmly connected to inquire about in metabolic illness is look into examining the cardiovascular defensive impacts of hexarelin[2]. The peptide can improve cardiac function in the setting of chronic heart failure, protect heart muscle following a heart attack, and reduce the formation of atherosclerotic plaques. Recently, studies designed to test the magnitude of hexarelin’s effect on the health of cardiomyocytes has revealed that the peptide is able to reduce scar formation following a heart attack. In fact, mice given hexarelin following cardiac ischemia show significant improvement in several cardiac parameters after just 14 days. Long-term remodeling is also favorably influenced, reducing the severity of the lifelong complications that often follow after a heart attack[3], [4].

What Is Hexarelin?
Hexarelin (additionally called examorelin) is a manufactured ghrelin/development hormone secretagogue like and got from GHRP-6. The hexapeptide comprises of His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys, making it like GHRP-6 except for the methyl-tryptophan at the subsequent position.

What Does Hexarelin Do?
Like GHRP-6, hexarelin causes significant, portion subordinate increase in development hormone. In fact, hexarelin causes more significant increase in development hormone than normally emitted development hormone-discharging hormone portion.

Not at all like GHRP-6, hexarelin doesn’t deliver significant changes in prolactin, adrenocorticotropic hormone, or cortisol. It has no impact on glucose levels, luteinizing hormone, follicle-invigorating hormone, or thyroid-animating hormone.

Hexarelin Metabolic Research
The primary applications for hexarelin research effects on metabolism revolve around insulin resistance and lipid metabolism. Hexarelin has been appeared to considerably improve insulin obstruction in diabetic rodents through the initiation of PPARγ and beta cells of the pancreas. Research has proposed that hexarelin not just improves the working of existing beta cells however causes the pancreas to recoup and recover beta cells.

Lipid digestion is the second zone of metabolic research including hexarelin. Abnormal lipid metabolism is an independent risk factor for diabetes. Indeed, even in non-obese people, irregular lipid digestion can prompt the advancement of type 2 diabetes. Studies in non-obese mice with dysfunctional fat metabolism have revealed that hexarelin significantly improves plasma glucose levels, which in turn reduces insulin secretion from the pancreas and long-term risk for the development of diabetes.

Hexarelin Cardiac Research
There is a lot of research concentrating on the cardiovascular impacts of hexarelin. The peptide has solid cardioprotective advantages, especially in instances of cardia injury. In fact, hexarelin has been appeared to hinder apoptosis following myocardial localized necrosis. This, thusly, decreases the measure of harm done to the heart (infarct size) for the time being. A decrease in momentary harm prompts a decrease in scar arrangement and in this manner long haul difficulties. Mice treated with hexarelin following heart ischemia exhibited improved launch part, decreased vascular obstruction, and improved results contrasted with controls. Also, hexarelin has been appeared to decrease atherosclerotic stores in conduits, improving vascular wellbeing and lessening the danger of cardiovascular failure and stroke.

Hexarelin Protective Benefits
Hexarelin ensures skeletal muscle in mouse models by forestalling apoptosis and muscle squandering. This is especially valid in models of muscle-squandering conditions (for example chemotherapy treatment). Research recommends that hexarelin secures muscle tissue by managing calcium homeostasis. This effect is particularly important during episodes of muscle ischemia, in certain disease states, and during traumatic injury to the muscle.

Hexarelin and Chemotherapy
As noted above, hexarelin ensures a few distinct kinds of muscle tissue, especially during ischemic or low-supplement states. Hence, hexarelin has been of serious enthusiasm as a potential subordinate treatment for malignant growth. While there is some proof to demonstrate that hexarelin legitimately influences malignancy cells, the essential enthusiasm among researchers is in the capacity of hexarelin to ensure muscle tissue against the damaging effects of chemotherapy. Heart damage, specifically, is a regular reaction of chemotherapeutics, especially the platinum-based medications. By restricting muscle squandering, hexarelin might be useful in improving long haul endurance and even paces of reduction in malignant growth by permitting higher portions of in any case harmful medications to be utilized.

Hexarelin

Sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular formula: C47H58N12O6
Molar Mass: 887.04022
CAS number: 140703-51-1

All of our products are lab tested and the results are periodically published on the website.

Hexarelin HPLC

Hexarelin MS

Also known as: Hexarelin Acetate, HEX, Examorelin, L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide

Resources

[1] L. Maréchal et al., “The CD36-PPARγ Pathway in Metabolic Disorders,” Int. J. Mol. Sci., vol. 19, no. 5, May 2018.

[2] R. M. H. Mosa, Z. Zhang, R. Shao, C. Deng, J. Chen, and C. Chen, “Ramifications of ghrelin and hexarelin in diabetes and diabetes-related heart ailments,” Endocrine, vol. 49, no. 2, pp. 307–323, Jun. 2015.

[3] H. McDonald et al., “Hexarelin treatment jam myocardial capacity and decreases cardiovascular fibrosis in a mouse model of intense myocardial dead tissue,” Physiol. Rep., vol. 6, no. 9, p. e13699, May 2018.

[4] X. Zhang, L. Qu, L. Chen, and C. Chen, “Improvement of cardiomyocyte work by in vivo hexarelin treatment in streptozotocin-initiated diabetic rodents,” Physiol. Rep., vol. 6, no. 4, Feb. 2018.

[5] M. Maccario et al., “Metabolic balance of the development hormone-discharging action of hexarelin in man,” Metab. – Clin. Exp., vol. 44, no. 1, pp. 134–138, Jan. 1995.

[6] R. Mosa et al., “Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese insulin-safe Male MKR Mice,” Endocrinology, vol. 158, no. 10, pp. 3174–3187, Oct. 2017.

[7] Y. Mao, T. Tokudome, and I. Kishimoto, “The cardiovascular activity of hexarelin,” J. Geriatr. Cardiol. JGC, vol. 11, no. 3, pp. 253–258, Sep. 2014.

[8] X. Xu et al., “Constant organization of hexarelin constricts cardiovascular fibrosis in the suddenly hypertensive rodent,” Am. J. Physiol. Heart Circ. Physiol., vol. 303, no. 6, pp. H703-711, Sep. 2012.

[9] Y. Mama, L. Zhang, B. S. Launikonis, and C. Chen, “Development hormone secretagogues protect the electrophysiological properties of mouse cardiomyocytes separated from in vitro ischemia/reperfusion heart,” Endocrinology, vol. 153, no. 11, pp. 5480–5490, Nov. 2012.

[10] Y. Mama, L. Zhang, J. N. Edwards, B. S. Launikonis, and C. Chen, “Development hormone secretagogues shield mouse cardiomyocytes from in vitro ischemia/reperfusion injury through guideline of intracellular calcium,” PloS One, vol. 7, no. 4, p. e35265, 2012.

[11] A. Liantonio et al., “Development hormone secretagogues apply differential impacts on skeletal muscle calcium homeostasis in male rodents relying upon the peptidyl/nonpeptidyl structure,” Endocrinology, vol. 154, no. 10, pp. 3764–3775, Oct. 2013.

[12] G. Sirago et al., “Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia,” Sci. Rep., vol. 7, no. 1, p. 13017, Oct. 2017.

Peptides are stable at room temperature and can be stored in their initial packaging for several days to weeks. Otherwise, peptides can be stored at 4 °C or below. Peptides should be protected from intense light.

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Hexarelin (Examorelin) 2mg (price is per vial)

$27.47 If paid in BTC $21.97

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