Liothyronine T3, 5000mcg (50mcg/100tabs)
83.00$ If paid in BTC 66.40$
Liothyronine T3, 5000mcg 50mcg
•USA: $5 (3-7 business days)
•CA: $10.50 (3-7 business days)
•International: $39 (7-14 business days)
Quantity: 100 tabs
Packaging: Capsulated and in Mylar Bags
Total amount of active ingredient: 5000mcg
Liothyronine is a synthetic form of triiodothyronine (T3), a thyroid hormone used to treat hypothyroidism and myxedema coma. T3 is the metabolically active thyroid hormone, which causes feedback inhibition, and lowers elevated TSH levels. It increases metabolism in peripheral tissues and is indicated when there is an impaired conversion of T4 to T3 in peripheral tissues.
Liothyronine is the most potent form of thyroid hormone. As the salt of triiodothyronine (T3), it is chemically similar and pharmacologically equivalent to T3. As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body’s sensitivity to catecholamines (such as adrenaline) by permissiveness. As monotherapy or in combination therapy with SSRIs, liothyronine may also enhance the generation of new neurons in the central nervous system. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
In comparison to levothyroxine (T4), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
Physicians may use liothyronine instead of or in addition to levothyroxine (T4) for patients undergoing thyroid hormone withdrawal. When a patient has thyroid cancer or Graves’ disease, ablation therapy with radioactive iodine (131I) can be used to remove trace thyroid tissue that may remain after thyroidectomy (surgical excision of the gland). For 131I therapy to be effective, the trace thyroid tissue must be avid to iodine, which is achieved by elevating the patient’s TSH levels. For patients taking levothyroxine, TSH may be boosted by discontinuing levothyroxine for 3–6 weeks. This long period of hormone withdrawal is required because of levothyroxine’s relatively long biological half-life and may result in symptoms of hypothyroidism in the patient. The shorter half-life of liothyronine permits a withdrawal period of two weeks, which may minimize hypothyroidism symptoms. One protocol is to discontinue levothyroxine, then prescribe liothyronine while the T4 levels are falling, and finally stop the liothyronine two weeks before the radioactive iodine treatment.
Liothyronine may also be preferred for patients with myxedema coma because of its quicker onset of action when compared to levothyroxine.
Low-dose liothyronine has been shown to improve depression symptoms in patients with normal thyroid function who do not have adequate relief from their depression after trying several different antidepressants.
Thyroid Hormone Replacement
Liothyronine is an option for routine thyroid hormone replacement. It has a half-life of 24 hours. (although the stated biological half-life is 2.5 days). This compares to a half-life of 7 days with levothyroxine. The shorter half-life allows patients to know if they are taking too much (indicated by a heart rate>100 bpm for more than 24 hours or increased anxiety) or if they should take more (no increase in energy). It is recommended that labs be drawn monthly and the dose increased until the patient’s hypothyroid symptoms resolve.
Per the liothyronine product insert, the starting dose may start at 5 mcg daily and increase by 5 mcg every two weeks. However, it should be noted that liothyronine should be taken with levothyroxine when liothyronine is taken long-term to avoid potential heart rate and rhythm abnormalities. Taking both levothyroxine and liothyronine separately allows for optimizing of reverse T3 and resolution of potential conversion problems of T4 to T3. Peripheral conversion problems are common when there is physiological stress (this will be felt as increased fatigue).
Any person with hypersensitivity to liothyronine sodium or any active ingredient of the formulation should not be on this medication. If there is uncorrected adrenal insufficiency or thyrotoxicosis, a different approach to therapy must be considered.
Liothyronine may cause a number of side effects, mostly similar to symptoms of hyperthyroidism, which include:
- weight loss
- upset stomach
- stomach cramps
- excessive sweating
- increased appetite
- changes in menstrual cycle
- sensitivity to heat
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Also known as: 3,3′,5-Triiodothyronine, Cytomel, Liothyronine, Liothyronine Sodium, T3 Thyroid Hormone, Thyroid Hormone, T3, Triiodothyronine